Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation
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Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.
Dietary flavonoids, including the citrus flavanone hesperetin, may have stimulatory effects on cytoprotective intracellular signalling pathways. In primary mouse cortical neurone cultures, but not SH-SY5Y human neuroblastoma cells or human primary dermal fibroblasts (Promocells), hesperetin (100-300nM, 15min) caused significant increases in the level of ERK1/2 phosphorylation, but did not incre...
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Neuroprotective effects of estrone on NMDA-induced toxicity in primary cultures of rat cortical neurons are independent of estrogen receptors.
It has been hypothesized that some estrogenic metabolites with low hormonal activity, such as estrone or estriol, may serve as endogenous neuroprotective agents. Since estrone naturally occurs in abundance in the human brain, we evaluated its effects on the NMDA-induced toxicity in primary cultures of the rat cortical neurons. The results showed that NMDA (1 mM) had toxic effect on the rat cort...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2008
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2008.04.056